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J Dent Res 50(3): 609-612, 1971
© 1971 International and American Associations for Dental Research
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Effect of ACTH and Adrenal Hormones on Cleft Palate Frequency in CD-1 Mice

FRANCES M. BLAUSTEIN 1, RAPLH FELLER 1, and SANFORD ROSENZWEIG 1

1 Tufts University School of Dental Medicine, Department of Social Dentistry, Boston, Massachusetts 02111, USA

Cortisone, hydrocortisone, corticosterone, epinephrine, ACTH, and the vehicle were injected into female CD-1 mice on days 11 to 14 of pregnancy, either intramuscularly, intraperitoneally, or subcutaneously. Cortisone and hydrocortisone significantly increased cleft palate frequency in all three injection routes, and corticosterone increased the frequency only in the intramuscular and subcutaneous routes.

Submitted on July 6, 1970






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