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J Dent Res 50(2): 371-373, 1971
© 1971 International and American Associations for Dental Research
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In Vivo Cariostatic Activity of Actinobolin

D. E. HUNT 1, J. M. NAVIA 1, and H. LOPEZ 1

1 Institute of Dental Research and Department of Microbiology, University of Alabama Medical Center, Birmingham, Alabama 35233, USA

The addition of 18.8 or 37.6 ppm of the antibiotic actinobolin to the diets of rats reduced significantly the total incidence of caries by 56 and 81 %, respectively. The reduction in caries obtained with actinobolin, compared with nontreated control rats and rats treated with 25 ppm of fluoride, indicates the potential use of this antibiotic as a cariostatic agent.

Submitted on February 3, 1970






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