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J Dent Res 49(6): 1513-1516, 1970
© 1970 International and American Associations for Dental Research
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In Vitro Susceptibility of Oral Spirochetes to Metronidazole

RONALD A. LE CLAIR 1 and LENA M. KEETIN 1

1 School of Public Health, University of California, Los Angeles, California 90024, USA

In vitro susceptibility of Borrelia buccalis, Borrelia vincentii, Treponema microdentium, Treponema pallidum, and Treponema reiterii to metronidazole, was ascertained by a tube susceptibility technique. The data obtained confirm and extend the conclusion of previous investigators that under in vitro conditions metronidazole will immobilize spirochetes. It appears that metronidazole will probably be an efficacious agent for the treatment of fusospirochetal infections.

Submitted on December 19, 1969






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