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J Dent Res 49(5): 1118-1124, 1970
© 1970 International and American Associations for Dental Research
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Degenerative Changes in the Superficial Epithelium of Chronic Hyperplastic Oral Mucosa: Clinicopathological and Histochemical Study

H. O. ARCHARD 1 and N. M. GLASS 1

1 Clinical Center, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland, USA 20014

An unusual homogeneous, eosinophilic material has been observed in the superficial epithelium of chronic hyperplastic oral mucosa. A study of 40 specimens of epulis fissuratum and 69 specimens of irritation fibroma revealed the material's association with chronic inflammation of the hyperplastic mucosa. Histochemically, it is rich in protein, sulfhydryl groups, tryptophan, and carbohydrate.

Submitted on October 15, 1969






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