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1 Department of Orthodontics, School of Dentistry, University of Nymegen, The Netherlands
Balanced embryologic development of the oral structures is vital for the fusion of the secondary palate. A malformation such as maxillomandibular ankylosis created by heterotopic cartilage in embryos of vitamin A-treated rats can lead to a chain of events that results in cleft palate and other malformations.
Submitted on September 8, 1969
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