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J Dent Res 48(3): 477-482, 1969
© 1969 International and American Associations for Dental Research
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Effect of Some Contraceptive Steroids on Growth and Development of Salivary Glands and Incidence of Dental Caries in Female Rats

FRANK T. Y. LIU 1 and HSIEN S. LIN 1

1 Department of Physiology, School of Dentistry, University of Missouri, Kansas City, Missouri 64110

Synthetic contraceptive steroids, ethynylestradiol and medroxyprogesterone acetate, were given individually in different doses to weanling female rats for eight weeks. In proportion to the doses administered, ethynylestradiol inhibited and medroxyprogesterone acetate stimulated the growth and development of the salivary glands. The steroid-treated rats exhibited an increase in dental caries incidence as compared to controls.

Submitted on November 14, 1968






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