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J Dent Res 47(3): 433-443, 1968
© 1968 International and American Associations for Dental Research
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Effect of Beta-2-Thienylalanine on Developing Mouse Tooth Germs In Vitro

EDWARD J. KOLLAR 1 and GRACE R. BAIRD 1

1 Department of Anatomy and Zoller Dental Clinic, University of Chicago, Chicago, Illinois

Tooth germs grown on Eagle's medium solidified with agar will differentiate in vitro. Normal development was suppressed by beta-2-thienylalanine (1 or 2 millimols per liter), but it proceeded when phenylalanine and beta-2-thienylalanine were present in equimolar concentrations. This effect may have been due to interference with protein metabolism in the dermal papillar cells.

Submitted on October 25, 1967






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