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J Dent Res 47(2): 286-290, 1968
© 1968 International and American Associations for Dental Research
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Experimental Mikulicz-Like Disease of the Lacrimal Gland, Induced by Repeated Subcutaneous Injections of 5-Hydroxytryptamine

ALVIN F. GARDNER 1

1 Bureau of Medicine, Food and Drug Administration, Department of Health, Education and Welfare, Washington, DC

A Mikulicz-like disease of the lacrimal glands occurred after six weekly subcutaneous injections of 10 mg of 5-hydroxytryptamine. The lacrimal glands of all experimental rats developed a dense lymphocytic infiltration that caused destruction of acinar cells.

Submitted on August 22, 1967






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