Beta-Aminopropionitrile Anorganic Bone in the Repair of Oral and Maxillofacial Wounds

¹ Bureau of Medicine, Food and Drug Administration, Department of Health, Education, and Welfare, Washington, D.C.

In this investigation, the anorganic bone chips occupied the space present in the incisor alveolus of albino rabbits and allowed osteogenic connective tissue to invade the macromolecular system of the anorganic bone chips. After 184 days, the implanted bone chips had new bone formation on their internal surfaces following tunnelization, and new bone surrounded the periphery of the implants. In the group receiving BAPN-anorganic bone implants, new bone formed in regions in which bone tissue is not normally produced, i.e., in a nonosteogenic site (subepithelial tissue). When BAPN-anorganic bone chips were implanted into the incisor alveolus of the rabbit, new bone formation developed in the basal half of the healing alveolus. The latter findings did not occur in the control group or in the group that received anorganic bone without BAPN. This investigation provides some evidence of an inductive potential after beta-aminoproprionitrile anorganic bone implants were made in the incisor alveoli of albino rabbits.