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1 C.S.R. Research Laboratories, East Roseville, N.S.W., Australia
The dissolution kinetics of synthetic hydroxyapatite pellets in an acetate buffer of pH 4.00 were investigated for stirred and unstirred systems both in the presence and absence of inorganic and organic phosphates. Dissolution was mass-transport controlled in the absence of forced convection. The organic (glucose, fructose, sucrose, and inositol) phosphates and inorganic (chain and ring) phosphates studied altered neither the dissolution rate in these systems nor the hydroxyapatite solubility. Fluoride ions reduced the rate of dissolution in unstirred systems by decreasing the hydroxyapatite solubility.
Ion disengagement from the kink sites on the crystal surface appeared to be rate determining when forced convection was sufficiently vigorous. Addition of organic or inorganic phosphates to such systems reduced the dissolution rate by a factor of from 2 to 8. These reductions were ascribed to the adsorption of the added phosphate anions at surface kink sites, with consequent retardation or poisoning of the ion disengagement step. Fluoride ions at higher concentrations in stirred systems exerted two effects: the first was a reduction in hydroxyapatite solubility; the second was a kinkpoisoning effect.
Submitted on March 29, 1966
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