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1 School of Dentistry, University of Pittsburgh, Pittsburgh, Pennsylvania
The normal closure of the palatal shelves in A/Hej mice occurs between 14-and 15
day of gestation. A single intraperitoneal injection of 1.25 mg. cortisone failed to induce cleft palate, while 2.5 mg. yielded an insignificant incidence of 7.5 per cent. However, a dosage of 5 mg. and 10 mg. produced 35.5 and 83.2 per cent induced cleft palates, respectively. The fetal resorptions increased with 5-mg. and 10-mg. doses, but the incidence was not considered unduly high. Failure of thalidomide to induce cleft palates in the dosage of 10 mg. and 15 mg. injected jected intraperitoneally should not be interpreted as evidence that the drug is not a teratogen. Further extensive investigation using different species, strain, dosage, and mode of administration may be explored.
This article has been cited by other articles:
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  D. M. Schwartz and A. P. Chaudhry Planimetric Studies of Mandibles in A/Jax Mice Born With Cortisone-Induced Cleft Palates Journal of Dental Research, September 1, 1968; 47(5): 725 - 732. [Abstract] [PDF]
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A. P. Chaudhry and S. Siar In Vitro Study of Fusion of Palatal Shelves in A/Jax Mouse Embryos Journal of Dental Research, January 1, 1967; 46(1): 257 - 260. [PDF]
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A. P. Chaudhry, S. Schwartz, J. Penn, and J. A. Schmutz JR Effects of Thyroxin on Palatogenesis, Fetal Resorptions, and Fetal Weights in A/Jax Mice Journal of Dental Research, November 1, 1966; 45(6): 1772 - 1774. [PDF]
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