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J Dent Res 45(5): 1548-1550, 1966
© 1966 International and American Associations for Dental Research
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Dose-Response of Submandibular Glands to Carcinogen Pellets in Rats and Hamsters

ANAND P. CHAUDLRY 1, RICHARD LIPOSKY 1, and JEFFERSON JONES 1

1 Department of Pathology, University of Pittsburgh School of Dentistry, Pittsburgh, Pennsylvania

An increase in the concentration of DMBA resulted in a corresponding increase in the incidence of malignant tumors of the submandibular glands in both hamsters and rats. Implantation of 0.2, 0.4, and 0.8 mg. carcinogen pellets in the submandibular glands of rats and hamsters resulted in different types of tumors in the two species. More squamous cell carcinomas were produced in the rats, while more sarcomas were produced in the hamsters. This statistically significant difference may be a result of tissue or species specificity. This hypothesis needs further investigation due to the complex nature of carcinogenesis.

Submitted on February 25, 1966






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