Effect of Parathyroid Extract on the Development of Wound Rupture Strength

¹ Department of Oral Diagnosis and Oral Medicine and Department of Pathology, University of Kentucky Medical Center, Lexington, Kentucky

The 1-day effect of parathyroid extract (PTE) on the development of rupture strength in wounds 1, 2, 3, 6, 9, 12, 15, and 18 days old in rats was investigated. Statistical analysis of the data revealed no significant PTE effect. The 3-day effect of PTE was studied in 6-, 9-, and 12-day-old wounds. Statistical analysis of the rupture strength data revealed a slight depressive PTE effect at day 6, a significant stimulating effect at day 9, and no significant effect at day 12. Evidence that appeared to support the hypothesis that PTE causes an increase in sulfate uptake by the connective tissue of the healing dermis was presented. This study suggested that the stimulation of a collagenolytic factor by PTE was not widely based in connective tissue.

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