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J Dent Res 45(3): 825-829, 1966
© 1966 International and American Associations for Dental Research
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Effect of Fluoride on Hypervitaminosis D in Rats

I. GEDALIA 1 and I. BINDERMAN 1

1 Alpha Omega Research and Postgraduate Centre, Hebrew University, Hadassah Faculty of Dentistry, Jerusalem, Israel

The effects of physiologic doses of fluoride on the toxic effects produced by hypervitaminosis D have been investigated in rats.

The results showed that fluoride reduces calcium levels in blood and urine and prevents bone resorption.

It is suggested that, in hypervitaminosis D, an increased concentration of fluoride ions in the tissue fluids induces fluorapatite precipitation.

Submitted on March 19, 1965




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A. Steier, I. Gedalia, A. Schwarz, and A. Rodan
Effect of Vitamin D and Fluoride on Experimental Bone Fracture Healing in Rats
Journal of Dental Research, July 1, 1967; 46(4): 675 - 680.
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