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J Dent Res 45(2): 364-371, 1966
© 1966 International and American Associations for Dental Research
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Biomechanical Control of Bone Growth and Development: A Histologic and Tetracycline Study

B. N. EPKER 1 and H. M. FROST 1

1 University of Detroit School of Dentistry and Henry Ford Hospital, Detroit, Michigan

The biomechanical postulates of Frost5 and Epker and Frost6 have been successfully given a test of observation by new histologic and tetracycline labeling studies, as well as by analysis of reports published by others. These postulates provide a basis for predicting changes in bone shape following changes in function and offer hope that we can learn to control surface drifts in bones to suit our own ends. It is proposed that the problem has been altered from one of achieving theoretical understanding of bone drifts, to one of achieving successful application of basic knowledge.

Submitted on March 19, 1965






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