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J Dent Res 45(2): 236-242, 1966
© 1966 International and American Associations for Dental Research

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Inhibition of Tooth Development with a Sclerosing Agent, Sodium Tetradecyl Sulfate

LAWRENCE R. SELINGER 1, W. HARRY ARCHER 1, and JOHN C. THONARD 1

1 Departments of Oral Surgery and Oral Pathology, University of Pittsburgh School of Dentistry, Pittsburgh, Pennsylvania

Sodium tetradecyl sulfate was selected as the sclerosing agent of choice and the effect of this drug on tooth development in 15 mongrel dogs was studied. The dogs were allotted to two groups and given one or two injections of sodium tetradecyl sulfate in predeterminated teeth.

Injections were made in 60 teeth, 2 injections of sodium tetradecyl sulfate and 2 of normal saline solution in each dog. The dogs were sacrificed at intervals from 1 day to 20 weeks. Radiographic and histologic studies were subsequently performed. Sodium tetradecyl sulfate, as employed in this experiment, was not completely effective in inhibiting the development of all of the injected teeth. Further studies have been suggested from which more favorable results are anticipated.

Submitted on October 10, 1963




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