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J Dent Res 45(1): 86-93, 1966
© 1966 International and American Associations for Dental Research
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The Effects of Tetracyclines on Teeth and Bones

ROBERT H. JOHNSON 1 and DAVID F. MITCHELL 1

1 Department of Oral Diagnosis, Indiana University School of Dentistry, Indianapolis, Indiana

Five experiments were conducted in an attempt to clarify some of the controversies found in the tetracycline literature. Gross and microscopic examinations were made of teeth and bones by means of ultraviolet light.

Four groups of adult male Wistar strain rats each were given a different tetracycline at recommended human oral therapeutic dosages, by weight, for 21 days. Discoloration or hypoplasia of the incisors was not seen in visible light, but varying degrees of yellow fluorescence under ultraviolet illumination were seen within as few as 8 days. Thus, a simple procedure was devised to test any new synthetic antibiotics such as rolitetracycline, or other fluorescent materials for the same properties.

The deposition of placentally acquired tetracyclines was demonstrated by feeding female rats throughout pregnancy and then examining the teeth and bones of their offspring. Lactating females were given the various homologues for 3 weeks after parturition. Fluorescent patterns were seen in the skeletons and teeth of their offspring.

Seventy-four weanlings from seven litters were allotted to experimental and control groups. The former were given 39 daily therapeutic doses of the tetracyclines, until they were 60 days old. No consistent difference in femur length or body weight of rats in the two groups was seen. Historadiograms did not reveal hypocalcification in these sections.

A tetracycline was used topically to reveal " marginal leakage" around two dental restorative materials.

Submitted on August 24, 1964




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