Osteogenic Activity of Odontoblasts in Transplanted Tooth Pulps

¹ College of Physicians and Surgeons, Columbia University; Department of Pathology, Francis Delafield Hospital Division, New York, New York

The intact dental pulp from adult rat incisors was transplanted subcutaneously in 1-to 4-day-old homologous rats to study the formation of calcified tissue by the odontoblast. After transplantation and the restoration of intact odontoblasts, both compact bone spicules and spongy bone that resembled dentin were formed.

At 24 days after transplantation, odontoblasts were surrounded by layers of compact and spongy bone.

Odontoblasts that previously had participated in dentin formation produced bone when no longer in contact with oral tissues. Cell formations resembling immature tooth structures were induced by odontoblasts acting on fibrous tissue adjacent to the transplants.

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