The Effect of Isoproterenol-induced Salivary-Gland Hypertrophy and Diet on the Chemistry of Rat Saliva
A. L. WILK 1 and
C. T. G. KING 1
1 U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Institute of Dental Research, Bethesda, Md.
The effects of two specific diets and of chronic treatment for 100 days with isoproterenol on the constituents of mixed salivary secretions were investigated in the Sprague-Dawley rat. The catechol amine treatment elevated the sodium ion concentration, while the cariogenic diet used caused an increase in the total protein levels and the Ca/P ratio as compared to the controls fed stock rat laboratory pellets. In this experiment the presence of alkaline phosphatase in the salivary secretion of the rat was correlated with age. It was demonstrable up to about 57 days but completely disappeared after 66 days of age.
Submitted on November 2, 1964
