Antifungal Properties of a New Endodontal Antiseptic Containing 5-Nitro-2-methylfurfuryl Ether

¹ Departments of Biochemistry and Endodontics, Loyola University School of Dentistry, Chicago, Illinois

In aqueous solution, NMFE, on the basis of concentration, was markedly superior to antibacterial and antiyeast activity. Aqueous solutions of PATS plus NMFE were equal in therapeutic effect to the solutions of NMFE alone and superior to the others. NMFE-impregnated paper points, with approximately 0.03 mg. of the impregnant per point, exhibited marked superiority over PATS-, SC-, and PATS-plus-SC-impregnated paper points carrying much greater amounts of total impregnant. PATS-plus-NMFE-impregnated paper points were not found to be very superior to the NMFE points in activity. However, although the former were the therapeutic equal of the latter, the stability of the PATS-plus-NMFE points appeared much greater.