F¹⁸ Recovery from Fetal Lambs Following Intravenous Injection into the Ewe

¹ Dental Research Center and the Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill, North Carolina

Two pregnant ewes were operated utilizing a technique which allows access to the [see figure in the PDF file] fetal circulation with the lamb in utero. F¹⁸ was injected intravenously into the ewe. The maternal and fetal blood levels of F¹⁸ were observed over a 2-hour period. These data were consistent with previous studies. In addition, total F¹⁸ recovery from the lambs was determined. Only 0.16 per cent and 0.42 per cent of the maternal dose were recovered in the respective experiments. These findings indicate that previously observed low fetal F¹⁸ blood levels were the result of limited placental transfer rather than rapid fetal plasma clearance of the tracer.

This article has been cited by other articles:

				P.R. Parker and J.W. Bawden Prenatal Fluoride Exposure: Measurement of Plasma Levels and Enamel Uptake in the Guinea Pig Journal of Dental Research, November 1, 1986; 65(11): 1341 - 1345. [Abstract] [PDF]