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J Dent Res 44(4): 734-749, 1965
© 1965 International and American Associations for Dental Research
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Reduction by Calciphylaxis of the Effects of Chronic Dihydrotachysterol Overdosage upon the Periodontium

IRVING GLICKMAN 1, HANS SELYE 1, and JEROME B. SMULOW 2

1 Ziskin Memorial Research Laboratory, Department of Periodontology, Tufts University School of Dental Medicine, Boston, Massachusetts
2 Institute of Medicine and Experimental Surgery, University of Montreal, Montreal, Canada

Chronic intoxication in rats with dihydrotachysterol (DHT) produced severe changes in the periodontium which included osteosclerosis, pronounced osteoid formation, bulbous distortion in the shape of the bone, and degeneration of the marrow and the periodontal ligament. Intraperitoneal administration of ferric hydroxide with dextran (Fe-Dex) induced calciphylaxis which reduced the toxic effects of DHT upon the periodontium.

Submitted on May 7, 1964






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