Effects of High Fluoride Intake on Utilization of Dietary Calcium and on Solubility of Calcified Tissues

¹ Department of Biochemistry, College of Medical Sciences, University of Minnesota, Minneapolis, Minnesota.

The utilization of dietary calcium, involving absorption, transport, and deposition of calcium by growing bones and teeth of rats was not affected by a high fluoride intake or by a high fluoride content of the calcified tissues. The retention and turnover of the calcium originally present in the calcified tissues was also not affected by the same circumstances.

The skeletal tissues and the enamel and dentin of higher fluoride contents consistently allowed a lesser amount of calcium to be dissolved by weakly acidic buffer solutions than did the corresponding tissues of lower fluoride contents.