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J Dent Res 44(1): 99-101, 1965
© 1965 International and American Associations for Dental Research
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The Effect of Oral Doses of Sodium Fluoride on Blood Pressure in Dogs

FRANK S. CARUSO 1 and HAROLD C. HODGE 1

1 Department of Pharmacology, University of Rochester School of Medicine and Dentistry, Rochester, New York

Oral doses of 1 mg. or of 5 mg. (0.06-0.15 mg/kg) of fluoride (as NaF) in solution given to anesthetized dogs did not depress the blood pressure. Doses of 10 mg/kg were also ineffective. A hypotensive response was observed in two of three dogs given 15 mg/kg and in three of three dogs given 23-36 mg/kg.

Submitted on February 4, 1964






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