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J Dent Res 43(4): 548-554, 1964
© 1964 International and American Associations for Dental Research
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The Teratogenic Effect of the Steroid Nucleus in the Rat

JEROLD J. BURESH 1 and THEODORE J. URBAN 1

1 School of Dentistry, Creighton University, Omaha, Nebraska

The teratogenic effect of the steroid nucleus was studied. Cholesterol (15 mg.) injected daily into female white rats from the 8th through the 14th day of pregnancy produced palatal abnormalities in a high percentage (56.8 per cent) of animals treated. A corresponding increase in adrenal weights and decrease in body weight were noted in the injected group.

Histological study of the heads of the embryos confirmed the gross observation of cleft palate in the offspring. It was observed that in some cases there appeared to be an epithelial bridge between the palatine shelves, while in others there was a deficiency of tissue.

Submitted on August 9, 1963






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