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J Dent Res 43(1): 86-91, 1964
© 1964 International and American Associations for Dental Research
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Direct Determination of Fibrinolytic Activity of Human Saliva

RICHARD G. TAYLOR 1, H. CHRIS DOKU 1, and JAMES ROMERO 1

1 Department of Oral Surgery, Tufts University School of Dental Medicine, Boston, Massachusetts

A method of determining directly fibrinolytic activity of human saliva, by means of modification of the human-plasma-euglobulin-fractionation method, was described. Using this technique, it was determined that:

1. Saliva was capable of splitting the fibrin bond producing lysis in a manner suggestive of an active fibrinolytic enzyme.

2. Small amounts of saliva in combination with streptokinase would rapidly transform plasminogen to plasmin, indicating the presence of a strong proactivator in saliva.

3. The saliva contained no plasminogen, nor was there any strong evidence that an activator of plasminogen was present in saliva.

[see figure in the PDF file] Submitted on February 12, 1963






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