Experimental Oral Carcinogenesis

¹ Department of Pathology, University of Texas Dental Branch, Houston, Texas

It is sometimes convenient to consider experimental carcinogenesis as dealing with localized small groups of cells. We must constantly keep in mind that these groups are an integral part of the individual. This concept of individuality, which is one of wholeness or complete integration, is extremely important in the field of oral cancer research. We must recognize that man is a complex biologic unit existing in a complex environment which influences the individual cells or groups of cells. Cancer of the mouth should be considered as a disease of the individual, with manifestations in the oral cavity. The similarities and differences between the skin and the oral mucosa were discussed in light of the foregoing statement. Application of the biologic principles of carcinogenesis to the oral mucous membrane was made.