Studies concerning the Antisolubility Effectiveness of Different Stannous Fluoride Prophylaxis Paste Mixtures

¹ Department of Biochemistry, Indiana University Medical Center, Indianapolis, Indiana

Various prophylaxis mixtures and abrasives with or without stannous fluoride or sodium fluoride were evaluated in vitro for antisolubility effectiveness. The more promising combinations were evaluated in vivo in the rat. The data indicated that silica powder alone affords some effectiveness against enamel dissolution, while lava pumice does not. When silicone in mineral oil was added to silica powder, the effectiveness was slightly greater. Prophylaxis mixtures with various sodium fluoride concentrations afforded less protection than results when stannous fluoride was used. In vivo data showed that aqueous stannous fluoride mixed with the prophylaxis abrasive was more effective than when solid stannous fluoride was added to the non-aqueous abrasive-containing system. The greatest antisolubility effectiveness resulted when an SnF₂ containing prophylaxis paste, an SnF₂ topical application, and the SnF₂-containing dentifrice were used in combination.