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J Dent Res 41(6): 1312-1321, 1962
© 1962 International and American Associations for Dental Research
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Comparison of Dental Caries Activity in Strains of Laboratory Rats

JAMES H. SHAW 1, DERRICK GRIFFITHS 1, and DAVID H. WOLLMAN 1

1 Harvard School of Dental Medicine, Boston, Massachusetts

The caries activities of 14 strains of laboratory rats have been studied over the past decade under closely controlled and highly cariogenic environmental conditions. Three strains of caries-susceptible rats and 2 strains of caries-resistant rats have been intensively studied and managed by careful breeding procedures to develop high predictability with respect to the phenotypic expression of experimental dental caries. An additional 9 strains have been studied on a survey basis to determine whether they had any unique potential in the study of dental caries. Of these, 5 strains had relatively high caries activities, and the remaining 4 had relatively low caries activities.

Submitted on December 4, 1961




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J. H. Shaw
Influences of Sodium, Calcium and Magnesium Trimetaphosphates on Dental Caries Activity in the Rat
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Inability of Low Levels of Sorbitol and Mannitol to Support Caries Activity in Rats
Journal of Dental Research, May 1, 1976; 55(3): 376 - 382.
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Influence of Cereal Incorporation in a Caries-Producing Diet on Caries Activity in Rats
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J. H. Shaw
Influence of Experimental Diets on Carious Lesions in the Occlusal Sulci and on the Smooth Surfaces of the Molars of Caries-Susceptible Rats
Journal of Dental Research, March 1, 1973; 52(2): 291 - 299.
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J. H. Shaw
Comparison of the Caries-Producing Properties of Diets 2700, 2000, and Modifications of 2000 in Rats
Journal of Dental Research, March 1, 1972; 51(2): 543 - 550.
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J. H. Shaw and D. Griffiths
Comparison of a Natural and a Purified Diet with Respect to Reproductive Ability and Caries Susceptibility
Journal of Dental Research, September 1, 1963; 42(5): 1198 - 1207.
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