Parotid Gland Extracts and Mice Submaxillary Glands

¹ Howard University College of Dentistry, Washington, D. C.

The following changes were observed in the serous or major portions of mice submaxillary glands following intramuscular injections of 0.3 mg. each of a standardized commercially prepared extract of bovine parotid glands: increased numbers of cells in the acinar parts of these glands; increased size of these cells near the center portions of these glands and/or near blood vessels; increased numbers of cytoplasmic vacuoles in the peripheral aspects of these glands; increased accumulations of glycogen deposits in the acini especially near the regional lymph glands; increased cellular population of the zona reticularis of the adrenals; increased mitogenic activity of cells adjacent to the ducts and marked proliferation of ductal epithelial cells; significantly increased size of vessels in association with the ducts and increased number of red blood cells within these vessels; increased accumulations of secretory products within the ducts; and increased size and number of sinus spaces within adjacent lymph glands, as well as increased size or dilation of afferent and efferent lymph vessels.