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J Dent Res 41(3): 617-623, 1962
© 1962 International and American Associations for Dental Research
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Effects of Salivary Fluoride on Enamel Solubility

WOLFGANG BUTTNER 1 and JOSEPH C. MUHLER 1

1 Department of Biochemistry, Indiana University Medical Center, Indianapolis, Indiana

The effects of salivary fluoride on enamel solubility have been investigated in the rat and by in vitro experiments in human saliva. Salivary fluoride was effective in reducing enamel solubility in weanling and adult rats which were provided with 1 mg. of fluoride daily by consuming fluoridated drinking water, by stomach tube, and by intraperitoneal injection. A fluoride concentration of at least 2.00 ppm is necessary in the human saliva to reduce enamel solubility significantly. A caries protective action of physiologic levels of salivary fluoride which are below 1.00 ppm concentration cannot be explained in terms of enamel solubility reduction, at least from these short-term animal studies.

Submitted on August 5, 1961






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