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J Dent Res 40(5): 921-928, 1961
© 1961 International and American Associations for Dental Research
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Mast-Cell Density in Diphenylhydantoin Sodium Gingival Hyperplasia

C. O. DUMMETT 1, T. E. BOLDEN 1, and J. C. ASHHURST 1

1 Veterans Administration Hospital, Tuskegee, Alabama, and Seton Hall College of Medicine and Dentistry, Jersey City, New Jersey

Mast-cell density was determined in specimens of gingiva from nine patients on a protracted course of diphenylhydantoin sodium therapy. It was quite variable and ranged from 0.47 to 146.00 mast cells per square millimeter of surface area. The data on the number of mast cells in sections of normal and inflamed gingiva were summarized. Apparent variations in response of mast cells are noted.

Speculations as to the role of hormones and other reactive materials in mast-cell response are drawn. The morphology and distribution of mast cells in our sample are described.

Submitted on July 18, 1960






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