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J Dent Res 40(5): 1020-1024, 1961
© 1961 International and American Associations for Dental Research
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The Effect of the Administration of Tetracycline on the Development of Teeth

GERRIT BEVELANDER 1, GLORIA K. ROLLE 1, and SIDNEY Q. COHLAN 1

1 Department of Histology, New York University College of Dentistry, and the Department of Pediatrics, New York University Medical Center

Tetracycline hydrochloride was administered to young rats in the amount of 5 mg. for each of 5 successive days.

Examination of the teeth following this treatment revealed the presence of fluorescent bands in the dentin and enamel in the incisors and molars corresponding to the 5 injections of the drug administered. In addition to the incorporation and retention of tetracycline as shown by the presence of the fluorophore, inhibition of calcification also occurred.

Submitted on February 3, 1961






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