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J Dent Res 40(3): 520-528, 1961
© 1961 International and American Associations for Dental Research
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Changes in the Connective Tissue of Rats Fed Toxic Diets Containing Molybdenum Salts

C. A. OSTROM 1, R. VAN REEN 1, and C. W. MILLER 1

1 Naval Medical Research Institute, National Naval Medical Center, Bethesda, Maryland

Molybdenum toxicity was produced in rats of the NMRI-D strain by adding 400 p.p.m. molybdenum as sodium molybdate to a basal purified diet.

Fifty per cent of the animals receiving the molybdenum showed markedly poorer growth responses, low hemoglobin levels, low hematocrit values, and developed mandibular exostoses.

The mandibles and teeth were subjected to histologic examination which indicated that the morphologic changes attendant on molybdenum toxicity resembled lathyrism except for minor details.

Submitted on October 6, 1960






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