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J Dent Res 40(2): 331-340, 1961
© 1961 International and American Associations for Dental Research
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Studies in the Design and Analysis of Dental Experiments. III. Sequential Analysis (Double Dichotomy)

NEAL W. CHILTON 1, JOHN W. FERTIG 1, and AUSTIN H. KUTSCHER 1

1 School of Public Health and Administrative Medicine of the Faculty of Medicine and the School of Dental and Oral Surgery, Columbia University, New York, N.Y.

The application of sequential analysis to an experiment on the relative effectiveness of two preparations of topical anesthetics in the oral cavity has been described. The advantages and disadvantages of this type of analysis as compared with that usually employed in clinical experimentation have been discussed. The relative merits of a one-sided versus a two-sided significance test were discussed and illustrated for the sequential design.

Submitted on July 5, 1960






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