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J Dent Res 40(1): 195-198, 1961
© 1961 International and American Associations for Dental Research
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Electrophoretic Separation of Human Serum Protein That Hydrolyzes Local Anesthetics

CHARLES E. BECKER 1

1 American Dental Association, Chicago, Illinois

Paper electrophoresis of normal human serum was carried out in barbital buffer and in the TEB buffer of Aronsson and Gronwall.2 The comparative localization of esterase activity toward benzoylcholine, acetylcholine, metabutethamine, meprylcaine, piperocaine, procaine, and butethamine was determined. The results of these experiments suggest the existence of several serum cholinesterases having variable activity in regard to the hydrolysis of the ester-type dental local anesthetics.

Submitted on June 8, 1960






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