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J Dent Res 39(2): 313-319, 1960
© 1960 International and American Associations for Dental Research
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Selective Colorimetric Determination of Local Anesthetics Containing a Tertiary Amine

EDWARD G. FELDMANN 1 and HENRY M. KOEHLER 1

1 Division of Chemistry, American Dental Association, Chicago 11, Illinois

The cis-aconitic anhydride method has been extended to the determination of other local anesthetics of dental interest which contain a tertiary amino group. Anesthetic compounds which do not contain a tertiary amine have been shown to give no interference with the method. The procedure has been found to have particular application see table in pdf in the analysis of commercial dosage forms which contain both procaine hydrochloride and butethamine hydrochloride in mixed solution.

Submitted on August 10, 1959
Revised on November 23, 1959






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