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J Dent Res 38(5): 947-950, 1959
© 1959 International and American Associations for Dental Research
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THE IN VITRO EFFECTS OF ANTIBIOTICS ON ORAL SPIROCHETES

E. G. HAMPP 1 and R. J. FITZGERALD 1

1 National Institute of Dental Research, National Institutes of Health, U. S. Public Health Service, Bethesda, Md.

A number of antibiotics have been tested in vitro against pure cultures of Borrelia vincentii, Borrelia buccalis, and the small oral treponemes. Penicillin, oleandomycin, novobiocin, celesticetin, streptolydigin, erythromycin, and vancomycin inhibited and killed these organisms at concentrations readily attainable in the oral cavity. The spirochetes were relatively resistant to polymyxin B and were markedly resistant to cycloserine and anisomycin.

Submitted on March 5, 1959
Revised on April 20, 1959






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