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J Dent Res 38(4): 776-781, 1959
© 1959 International and American Associations for Dental Research
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FURTHER OBSERVATIONS ON THE CARIOSTATIC EFFECT OF PHOSPHATES

F. J. MC CLURE 1 and A. MULLER JR. 1

1 National Institute of Dental Research, National Institutes of Health, Bethesda, Md.

1. A diet containing whole wheat flour and lactose autoclaved, and liver powder, produced caries to a significant extent in white rats.

2. Dietary supplements of Na2HPO4 and Ca(H2PO4)2 · H2O were highly cariostatic; precipitated basic calcium phosphate and CaHPO4 were not cariostatic. The addition of NaCl to the diet was instrumental in rendering CaHPO4 cariostatic and improved the cariostatic effect of Ca(H2PO4)2 · H2O.

3. When administered by intubation, Na2HPO4 was considerably less cariostatic than when ingested in the diet.

4. The results suggest that relative solubility in the oral cavity was a factor in the cariostatic action of the phosphates studied.

Submitted on January 12, 1959
Revised on February 23, 1959




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