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J Dent Res 37(4): 649-653, 1958
© 1958 International and American Associations for Dental Research
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THE EFFECT OF PILOCARPINE ON THE SUBMAXILLARY GLAND OF THE RAT

DAVID BIXLER PH.D.1, RICHARD C. WEBSTER PH.D.1, and JOSEPH C. MUHLER D.D.S., PH.D.1

1 Indiana University, Bloomington, Ind.

Pilocarpine, when given to adult male rats, had its most pronounced effect upon the acinar portion of the submaxillary salivary gland 2 to 5 hours after administration. This effect was an increased intensity of the periodic acid-Schiff reaction and a spreading out of the methyl-green pyronin (RNA) reaction in the cell cytoplasm. Prolonged administration of pilocarpine (daily for 12 weeks) produced no apparent pathosis in the submaxillary gland, although gross observations revealed that the drug regularly stimulated a profuse and voluminous flow throughout the entire experimental period.

Submitted on November 15, 1957
Revised on March 20, 1958






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