BIOCHEMICAL STUDIES ON ACUTE INFLAMMATION

II. THE EFFECT OF DILANTIN

¹ National Institute of Dental Research, National Institutes of Health, Public Health Service, U. S. Department of Health, Education and Welfare, Bethesda, Md.

1. An acute inflammatory reaction was induced in the antemolar region of the palates of rats receiving oral Dilantin therapy at levels of 50 and 200 mg. per kilogram daily. Quantitative chemical analyses of the tissues were performed before and at 30 minutes, 4 hours, 16 hours, 30 or 40 hours, and 3 days following stimulation.

2. The acid-soluble phosphorus fraction was significantly decreased from the quantities observed in normal rats both before and during the inflammatory response. Of the other chemical components studied, tyrosine, proline, hydroxyproline, hexosamine, ribonucleic acid, deoxyribonucleic acid, inorganic phosphorus, residue phosphorus, and total water, no significant departures from normal behavior were observed except for a slightly diminished increase in total water.