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J Dent Res 36(6): 883-885, 1957
© 1957 International and American Associations for Dental Research
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THE EFFECT OF PILOCARPINE ON DENTAL CARIES IN THE RAT

JOSEPH C. MUHLER D.D.S., PH.D.1, DAVID BIXLER PH.D.1, and WILLIAM G. SHAFER D.D.S., M.S.1

1 Indiana University, Bloomington and Indianapolis, Ind.

The effect of increased salivary flow, as produced by the administration of pilocarpine, on the incidence of dental caries in the rat was studied. It was found that 2 mg. of pilocarpine given daily significantly reduced the dental caries incidence, while 6 and 12 mg. daily did not reduce caries significantly. Apparently the salivary flow-dental caries relationship is not a simple one. Desiccated thyroid was found to be a potent anticariogenic agent, as has been reported in previous studies.

Submitted on February 21, 1957






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