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J Dent Res 36(5): 769-770, 1957
© 1957 International and American Associations for Dental Research
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THE PRODUCTION OF ACIDS FROM GLUCOSE BY ORAL MICROORGANISMS: ACIDS OF THE KREBS CYCLE

ISAAC NEUWIRTH 1 and PAUL J. BAERGER 1

1 Department of Pharmacology and Therapeutics, and the Murry and Leonie Guggenheim Foundation, Institute for Dental Research, New York University College of Dentistry, New York, N. Y.

1. By the use of paper chromatography, it has been demonstrated that the following acids of the Krebs cycle are produced by the action of oral microorganisms on glucose: malic, oxalacetic, alpha-ketoglutaric, succinic, fumaric, pyruvic, and lactic.

2. The concentration of these acids increases with time, save for lactic and citric acids.

3. The amounts of these acids produced under our experimental conditions bear no relation to the clinical caries picture.

Submitted on November 18, 1956






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