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J Dent Res 36(4): 507-512, 1957
© 1957 International and American Associations for Dental Research
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PLACENTAL PERMEABILITY TO BACTERIAL TOXINS

HOLMES T. KNIGHTON, D.D.S.1, SEYMOUR J. KRESHOVER, D.D.S., M.D., PH.D.1, and JAMES A. HANCOCK, JR., M.S.1

1 Departments of Microbiology and Dental Research, The Medical College of Virginia, Richmond, Va.

1. The exotoxin of Cl. tetani failed to cross the placenta of rabbits, guinea pigs, and rats in detectable amounts.

2. Similar tests for the transplacental passage of Cl. oedematiens in rabbits, and C. diphtheria in rabbits and guinea pigs were, likewise, negative.

3. The intracardial, intraperitoneal, and intraplacental administration of dextran and hyaluronidase failed to enhance the passage of tetanus toxin into the fetuses of rabbits.






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