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J Dent Res 36(3): 372-374, 1957
© 1957 International and American Associations for Dental Research
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EFFECT OF 2-ACETYLAMINO-1,3,4-THIADIAZOLE-5-SULFONAMIDE (DIAMOX) ON DENTAL CARIES RESISTANCE IN HAMSTERS

DAVID F. MITCHELL 1 and MARILYN J. JOHNSON 1

1 School of Dentistry, University of Minnesota, Minneapolis, Minn.

When 2-acetylamino-1,3,4-thiadiazole-5-sulfonamide, a diuretic, was fed to caries-resistant hamsters at the rate of .015 to .025 per cent of a caries-producing diet, ad libitum, for 98 days, they developed nearly 3 times as much dental caries as their caries-resistant controls. The treated animals gained less weight than the controls, but no differences were detected in salivary pH or water consumption.

Submitted on May 29, 1956






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