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J Dent Res 36(2): 237-244, 1957
© 1957 International and American Associations for Dental Research
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THE EFFECTIVENESS OF A TYROTHRICIN DENTIFRICE IN THE CONTROL OF DENTAL CARIES

F. R. SHIERE 1

1 Tufts University, School of Dental Medicine, Boston, Mass.

A group of tyrothricin tooth pastes containing insoluble sodium metaphosphate as a component of the polishing agent produced a reduction in hamster caries in comparison with a control tooth paste.

A selected tooth paste containing 0.05 per cent tyrothricin and insoluble sodium metaphosphate as a component of the polishing agent was found effective in reducing dental caries in children in a controlled clinical study. The incidence of new decayed and filled permanent tooth surfaces was reduced by 35 per cent after 1 year and by 26 per cent after a total of 2 years' brushing with the tyrothricin tooth paste.

The reductions in caries are highly significant, and may be ascribed to the presence of the tyrothricin, since identical oral hygiene procedures were followed in both experimental and control groups.

Submitted on December 15, 1955






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