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J Dent Res 36(1): 95-99, 1957
© 1957 International and American Associations for Dental Research
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EXPERIMENTAL DENTAL CARIES

IX RELATIONSHIP OF THYROID FUNCTION TO DENTAL CARIES EXPERIENCE IN SALIVARY-ADENECTOMIZED RATS

JOSEPH C. MUHLER 1 and WILLIAM G. SHAFER 1

1 Indiana University, Department of Chemistry and School of Dentistry, Bloomington and Indianapolis, Ind.

The anticariogenic effectiveness of desiccated thyroid is not evident when this material is fed in the diet to rats with the major salivary glands removed. Similarly, the cariogenic effectiveness of thiouracil, while still manifested in salivary-adenectomized animals, seems to be reduced in comparison to the cariogenic effect of this compound when fed to rats with intact salivary glands. These observations lend credence to the hypothesis that the salivary glands are directly involved in the thyroid-dental caries relationship.

Submitted on August 18, 1955






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