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J Dent Res 36(1): 68-74, 1957
© 1957 International and American Associations for Dental Research

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THE EFFECT OF ALLOXAN DIABETES ON CARIES INCIDENCE IN THE ALBINO RAT

MARTIN S. NICHOLS 1 and JAMES H. SHAW 1

1 Harvard School of Dental Medicine, Boston, Mass.

A diabetic syndrome was produced in caries-susceptible rats by the intravenous injection of alloxan monohydrate. The diabetic rats had high blood glucose levels, a high incidence of cataracts, a slow rate of growth, low adult body weights and an unusually high rate of food consumption.

No statistically significant difference was found between the number of carious molars, the number of carious lesions and the extent of carious lesions in the molar teeth of normal albino rats and their alloxan-diabetic littermates which were maintained on a cariogenic diet for 103 days.







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