HISTOLOGIC CHANGES IN THE HAMSTER CHEEK POUCH DURING EARLY HYDROCARBON CARCINOGENESIS

¹ Division of Dental Research and Department of Pathology, University of Rochester School of Medicine and Dentistry, Rochester, N. Y.

A study has been described wherein the early changes associated with 9,10-dimethyl-1,2-benzanthracene carcinogenesis in the hamster cheek pouch have been observed by conventional histologic methods. The pouch wall appeared to pass through 4 distinct histologic gradations before the appearance of definite neoplasms. These were inflammation, degeneration, regeneration, and hyperplasia. Descriptions and accompanying illustrations of each of the 4 stages plus the type of tumor which resulted have been included. A brief discussion comparing skin and oral mucosa and their reaction to experimental tumor induction has also been presented.

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