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J Dent Res 35(3): 399-403, 1956
© 1956 International and American Associations for Dental Research
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THE EFFECTS OF PENICILLIN AND TERRAMYCIN ON DENTAL CARIES AND CERTAIN ORAL MICROFLORA IN HUNT-HOPPERT CARIES-SUSCEPTIBLE RATS

S. ROSEN 1, H. S. RAGHEB 1, C. A. HOPPERT 1, and H. R. HUNT 1

1 Departments of Bacteriology, Zoology, and Chemistry, Michigan State University, East Lansing, Mich.

Penicillin at a concentration of 500 units per gram of feed effectively inhibited dental caries and several groups of acidogenic bacteria usually associated with dental caries. In contrast, Terramycin at a concentration of 0.025 per cent in the feed retarded dental caries only slightly although the bacteriologic findings were quite similar to those in the penicillin group. These results suggest that organisms other than those considered in this study may play an essential role in the etiology of dental caries in these animals.

Submitted on January 14, 1955






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